Ozkul Y, Donmez H, Erenmemisoglu A, Demirtas H, Imamoglu N
Department Medical Biology and Genetics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Mutagenesis. 1997 Jul;12(4):285-7. doi: 10.1093/mutage/12.4.285.
Maras Powder is a kind of smokeless tobacco widely used in lieu of cigarettes in the South-Eastern region of Turkey. In this study, we have evaluated micronuclei in buccal mucosa cells of habitual Maras Powder users. Therefore, we divided our subjects into three groups--smokeless tobacco users, smokers and non-smokers/non-users. The mean percentage of micronucleated (MN) cells was significantly higher in smokeless tobacco users and smokers than in non-smokers/non-users (P < 0.01) [corrected]. The mean percentage of MN cells was 1.86 +/- 0.26 in users and 1.99 +/- 0.30 in smokers. There was no difference between the mean percentage of MN cells in these two groups. In conclusion, the genotoxic effect of smokeless tobacco should be considered in addition to other known hazards.
马拉斯粉是一种无烟烟草，在土耳其东南部被广泛用于替代香烟。在本研究中，我们评估了习惯性使用马拉斯粉者颊黏膜细胞中的微核。因此，我们将受试者分为三组——无烟烟草使用者、吸烟者以及非吸烟者/非使用者。无烟烟草使用者和吸烟者的微核化（MN）细胞平均百分比显著高于非吸烟者/非使用者（P < 0.01）[校正后]。使用者的MN细胞平均百分比为1.86±0.26，吸烟者为1.99±0.30。这两组的MN细胞平均百分比之间没有差异。总之，除了其他已知危害外，还应考虑无烟烟草的遗传毒性作用。
