Kumm M, Seeling W
Universitätsklinik für Anaesthesiologie, Universität Ulm.
Reg Anaesth. 1991 May;14(3):56-9.
A 72-year-old female patient was scheduled for abdominal surgery with epidural block in combination with general anesthesia. An 18 G epidural catheter was inserted through an 18 G Tuohy needle between T12 and L1 using the midline approach and the 'loss of resistance' technique. A test dose of 13 ml bupivacaine 0.25% showed no effect and a bolus of 12 ml bupivacaine 0.25% was added 8 min later. Bilateral analgesia between S5 and C4 developed over the following 17 min but was not accompanied by any cardiovascular or respiratory depression. The patient became sleepy and was finally intubated after the administration of thiopentone 175 mg and pancuronium 6 mg. There were no objections to surgery, so the hemicolectomy was continued as planned. Intraoperatively the systolic blood pressure dropped twice, to a minimum of 105 mm Hg, coinciding with eventration of the intestine, but this was reversed immediately on administration of a vasoconstrictor. Extubation of the patient was possible 90 min later on the termination of surgery, when the level of anesthesia had reached T2. A spinal X-ray with radiopaque dye showed a typical intrathecal distribution. Most remarkable in this case is the stability of the cardiovascular function which in our opinion is related to the 0.25% solution. Serious complications of an inadvertent dural puncture can be avoided or alleviated with this concentration if the epidural block is to be combined with general anesthesia.
一名72岁女性患者计划接受硬膜外阻滞联合全身麻醉下的腹部手术。采用中线入路和“阻力消失”技术,通过一根18G的Tuohy针在T12和L1之间插入一根18G的硬膜外导管。13ml 0.25%的布比卡因试验剂量未见效果,8分钟后追加12ml 0.25%的布比卡因推注量。在接下来的17分钟内出现了S5至C4水平的双侧镇痛,但未伴有任何心血管或呼吸抑制。患者变得嗜睡,在给予175mg硫喷妥钠和6mg潘库溴铵后最终插管。手术无异议,因此按计划继续进行半结肠切除术。术中收缩压两次下降,最低降至105mmHg,与肠管脱出同时发生,但在给予血管收缩剂后立即恢复。手术结束90分钟后,当麻醉平面达到T2时患者可以拔管。带有不透X线染料的脊柱X线片显示出典型的鞘内分布。该病例最显著的是心血管功能的稳定性,我们认为这与0.25%的溶液有关。如果硬膜外阻滞联合全身麻醉,使用该浓度可避免或减轻意外硬膜穿刺的严重并发症。