Lopez Eliot, Jones Deborah L, Ishii Mary, Tobin Jonathan N, Weiss Stephen M
University of Miami Miller School of Medicine.
Am J Infect Dis. 2007;3(4):240-247. doi: 10.3844/ajidsp.2007.240.247.
Antiretroviral (ARV) medication for substance users has been a controversial issue with respect to whether current substance users can successfully maintain their medication regimens. This study compared ARV adherence across current substance users, former substance users and those with no history or current use and the relative impact of a medication adherence intervention on all three groups. Of the 481 predominantly African American and Latina women from Miami, New York and New Jersey enrolled in the SMARTEST Women's Program, 338 participants were prescribed antiretroviral medication at study entry. All three groups, current users (n=60), former users (n=107) and never users (n=171), reported relatively high levels of adherence at baseline. Of those participants with less than 80% adherence at baseline, former users showed the most significant decrease in viral load post-intervention and at long term (two year) follow-up. These findings suggest former users to be the most reliable source of self-reported adherence and to profit most from the study intervention. They also suggest that additional research on targeted interventions for current substance users may be necessary to improve medication adherence for this group of women living with HIV.
对于吸毒者而言，抗逆转录病毒（ARV）药物治疗在当前吸毒者能否成功维持药物治疗方案方面一直是个有争议的问题。本研究比较了当前吸毒者、既往吸毒者以及无吸毒史或当前未吸毒者的抗逆转录病毒治疗依从性，以及药物依从性干预对这三组人群的相对影响。在参加“最聪明女性项目”的481名主要为非裔美国人和拉丁裔女性中，她们来自迈阿密、纽约和新泽西，338名参与者在研究开始时被开了抗逆转录病毒药物。三组人群，即当前吸毒者（n = 60）、既往吸毒者（n = 107）和从未吸毒者（n = 171），在基线时报告的依从性水平相对较高。在基线时依从性低于80%的参与者中，既往吸毒者在干预后和长期（两年）随访时病毒载量下降最为显著。这些发现表明，既往吸毒者是自我报告依从性最可靠的来源，并且从研究干预中获益最多。它们还表明，可能有必要对当前吸毒者的针对性干预措施进行更多研究，以提高这组感染艾滋病毒女性的药物依从性。
