Naylor C J, Al-Ankari A R, Al-Afaleq A I, Bradbury J M, Jones R C
Department of Veterinary Pathology, University of Liverpool, Neston, Wirral, England.
Avian Pathol. 1992;21(2):295-305. doi: 10.1080/03079459208418844.
Groups of 1-day-old turkey poults from a parent flock free of antibodies to turkey rhinotracheitis virus (TRTV) and the pathogenic mycoplasmas, were infected by eyedrop with virulent TRTV, with Mycoplasma gallisepticum (Mg) or with both agents together. Dual infection resulted in increased morbidity compared with those groups given single infections. The presence of the Mg in the dual infection had no apparent effect on the pathogenesis of the virus, but the virus caused the Mycoplasma to be more invasive. Mg infection caused a transient depression in TRTV ELISA antibody titres at 29 days post-inoculation. At 14 days post-infection Mg haemagglutination inhibition (HI) and rapid serum agglutination (RSA) titres were higher (P <0.01) in the mixed infection group compared with those infected with Mg alone, but there was no significant difference between ELISA antibody titres of these two groups.
选取来自无火鸡鼻气管炎病毒（TRTV）和致病性支原体抗体的亲代鸡群的1日龄火鸡雏，通过滴眼法分别感染强毒TRTV、鸡败血支原体（Mg）或同时感染这两种病原体。与单一感染组相比，双重感染导致发病率增加。双重感染中Mg的存在对病毒的发病机制没有明显影响，但病毒使支原体更具侵袭性。Mg感染导致接种后29天TRTV ELISA抗体滴度出现短暂下降。感染后14天，混合感染组的Mg血凝抑制（HI）和快速血清凝集（RSA）滴度高于单独感染Mg的组（P<0.01），但这两组的ELISA抗体滴度之间没有显著差异。
