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一位青少年同时患有韦格纳肉芽肿病和慢性球孢子菌病。

An adolescent with both Wegener's Granulomatosis and chronic blastomycosis.

机构信息

Division of Child health, Sultan Qaboos University Hospital, Muscat, Oman.

出版信息

Pediatr Rheumatol Online J. 2008 Aug 3;6:13. doi: 10.1186/1546-0096-6-13.

DOI:10.1186/1546-0096-6-13
PMID:18673582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2518148/
Abstract

We report a case of Wegener's Granulomatosis (WG) associated with blastomycosis. This appears to be the first case report of WG co-existing with a tissue proven blastomycosis infection. The temporal correlation of the two conditions suggests that blastomycosis infection (and therefore possibly other fungal infections), may trigger the systemic granulomatous vasculitis in a predisposed individual; a provocative supposition warranting further study.

摘要

我们报告了一例韦格纳肉芽肿(WG)合并球孢子菌病的病例。这似乎是首例WG 与组织证实的球孢子菌感染共存的病例报告。这两种情况的时间相关性表明,球孢子菌感染(因此可能还有其他真菌感染)可能在易感个体中引发全身性肉芽肿性血管炎;这一推测性假设值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd1/2518148/95b563867b00/1546-0096-6-13-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd1/2518148/95b563867b00/1546-0096-6-13-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd1/2518148/95b563867b00/1546-0096-6-13-1.jpg

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本文引用的文献

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Effector memory T cells as driving force of granuloma formation and autoimmunity in Wegener's granulomatosis.效应记忆T细胞作为韦格纳肉芽肿中肉芽肿形成和自身免疫的驱动力。
J Intern Med. 2006 Sep;260(3):187-91. doi: 10.1111/j.1365-2796.2006.01698.x.
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Microscopic polyangitis triggered by fungal infection.
Hokkaido Igaku Zasshi. 2006 Jan;81(1):5-8.
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Blastomycosis in Ontario, 1994-2003.1994 - 2003年安大略省的芽生菌病
Emerg Infect Dis. 2006 Feb;12(2):274-9. doi: 10.3201/eid1202.050849.
4
Wegener's granulomatosis: evolving concepts in treatment.韦格纳肉芽肿:治疗理念的演变
Semin Respir Crit Care Med. 2004 Oct;25(5):491-521. doi: 10.1055/s-2004-836143.
5
Antineutrophil cytoplasmic antibody vasculitis associated with mycobacterium avium intracellulare infection.与鸟分枝杆菌胞内感染相关的抗中性粒细胞胞浆抗体血管炎
J Rheumatol. 2005 Aug;32(8):1610-2.
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Anti-neutrophil cytoplasmic antibodies (ANCA) in malaria.疟疾中的抗中性粒细胞胞浆抗体(ANCA)
Indian J Malariol. 2002 Sep-Dec;39(3-4):51-9.
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An ocular cat-scratch disease patient positive for cytoplasmic anti-neutrophil cytoplasmic antibody.一名胞浆型抗中性粒细胞胞浆抗体阳性的眼部猫抓病患者。
Graefes Arch Clin Exp Ophthalmol. 2001 Nov;239(11):882-5. doi: 10.1007/s004170100374.
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Cytomegalovirus infection in systemic necrotizing vasculitis: causative agent or opportunistic infection?系统性坏死性血管炎中的巨细胞病毒感染:病原体还是机会性感染?
Rheumatol Int. 2000 Dec;20(1):35-8. doi: 10.1007/s002960000063.
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Seroprevalence and disease association of antineutrophil cytoplasmic autoantibodies and antigens in HIV infection.抗中性粒细胞胞浆自身抗体及抗原在HIV感染中的血清阳性率和疾病关联
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c-ANCA positivity in a Belgian patient with pulmonary paracoccidioidomycosis.一名患有肺副球孢子菌病的比利时患者的胞浆型抗中性粒细胞胞浆抗体阳性。
Eur Respir J. 1997 Oct;10(10):2419-22. doi: 10.1183/09031936.97.10102419.