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计算机断层扫描上的结石衰减和皮肤到结石的距离可预测冲击波碎石术导致的结石破碎情况。

Stone attenuation and skin-to-stone distance on computed tomography predicts for stone fragmentation by shock wave lithotripsy.

作者信息

Perks Alexandra E, Schuler Trevor D, Lee Jason, Ghiculete Daniela, Chung Dae-Gyun, D'A Honey R John, Pace Kenneth T

机构信息

Division of Urology, Department of Surgery, and the Department of Radiology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.

出版信息

Urology. 2008 Oct;72(4):765-9. doi: 10.1016/j.urology.2008.05.046. Epub 2008 Jul 31.

Abstract

OBJECTIVES

To determine whether stone attenuation and the skin-to-stone distance (SSD) can predict for stone fragmentation by SWL independently. Identifying the factors predictive of shock wave lithotripsy (SWL) outcome would help streamline the care of patients with stones.

METHODS

A retrospective review was performed of 111 patients undergoing initial SWL for a solitary, 5-20 mm, renal calculus. Stone size, location, attenuation value, and SSD were determined on pretreatment noncontrast computed tomography. The outcome was categorized as stone free, complete fragmentation <5 mm, and incomplete fragmentation >or=5 mm or unchanged at 2 weeks on kidney/ureter/bladder radiography.

RESULTS

After SWL, 44 (40%) were stone free, 27 (24%) had complete fragmentation, and 40 (36%) of 111 patients had incomplete fragmentation. The stone attenuation of the successfully treated patients (stone free and complete fragmentation groups) was 837 +/- 277 Hounsfield units (HU) vs 1092 +/- 254 HU for those with treatment failure (incomplete fragmentation; P < .01). The mean SSD also differed: 9.6 cm +/- 2.0 vs 11.1 cm +/- 2.5 for the successful treatment group vs the treatment failure group, respectively (P = .01). On multivariate analysis, the factors that independently predicted the outcome were stone attenuation, SSD, and stone composition. When patients were stratified into 4 risk groups (stone <900 HU and SSD <9.0 cm, stone <900 HU and SSD >or=9.0 cm, stone >or=900 HU and SSD <9.0 cm, and stone >or=900 HU and SSD >or=9.0 cm), the SWL success rate was 91%, 79%, 58%, and 41%, respectively (odds ratio 7.1, 95% confidence interval 1.6-32 for <900 HU and SSD <9.0 cm group vs other 3 risk groups; P = .01).

CONCLUSIONS

The results of our study have shown that a stone attenuation of <900 HU, SSD of <9 cm, and stone composition predict for SWL success, independent of stone size, location, and body mass index. These factors will be considered important in the prospective design of a SWL treatment nomogram at our center.

摘要

目的

确定结石衰减值和皮肤至结石距离(SSD)能否独立预测体外冲击波碎石术(SWL)后结石的粉碎情况。识别预测冲击波碎石术(SWL)治疗结果的因素将有助于优化结石患者的治疗。

方法

对111例因单发、直径5 - 20 mm肾结石接受初次SWL治疗的患者进行回顾性研究。在治疗前的非增强计算机断层扫描上确定结石大小、位置、衰减值和SSD。结局分为结石清除、完全粉碎至<5 mm、不完全粉碎至≥5 mm或2周时在肾脏/输尿管/膀胱平片上结石无变化。

结果

SWL治疗后,44例(40%)结石清除,27例(24%)完全粉碎,111例患者中有40例(36%)不完全粉碎。成功治疗的患者(结石清除和完全粉碎组)的结石衰减值为837±277亨氏单位(HU),而治疗失败(不完全粉碎)的患者为1092±254 HU(P <.01)。平均SSD也不同:成功治疗组为9.6 cm±2.0,治疗失败组为11.1 cm±2.5(P =.01)。多因素分析显示,独立预测治疗结果的因素为结石衰减值、SSD和结石成分。当患者被分为4个风险组(结石<900 HU且SSD<9.0 cm、结石<900 HU且SSD≥9.0 cm、结石≥900 HU且SSD<9.0 cm、结石≥900 HU且SSD≥9.0 cm)时,SWL成功率分别为91%、79%、58%和41%(<900 HU且SSD<9.0 cm组与其他3个风险组相比,优势比为7.1,95%置信区间为1.6 - 32;P =.01)。

结论

我们的研究结果表明,结石衰减值<900 HU、SSD<9 cm和结石成分可预测SWL治疗成功,与结石大小、位置和体重指数无关。在我们中心,这些因素在SWL治疗列线图的前瞻性设计中将被视为重要因素。

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