Nassenstein Kai, Breuckmann Frank, Lehmann Nils, Schmermund Axel, Hunold Peter, Broecker-Preuss Martina, Sandner Torleif A, Halle Martin, Mann Klaus, Jöckel Karl-Heinz, Heusch Gerd, Budde Thomas, Erbel Raimund, Barkhausen Jörg, Möhlenkamp Stefan
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, Essen, Germany.
Int J Cardiovasc Imaging. 2009 Jan;25(1):71-9. doi: 10.1007/s10554-008-9337-x. Epub 2008 Aug 3.
To assess left ventricular volumes and mass by cardiac magnetic resonance imaging in relation to conventional cardiovascular risk factors and coronary atherosclerotic plaque burden in master marathon runners aged > or =50 years.
Cardiac MRI was performed in 105 clinically healthy male marathon runners (mean age 57.3 +/- 5.7 years, range 50-71 years) on a 1.5 T MR system (Avanto, Siemens, Germany). Cine steady state free precession images in standard long and short axes views were acquired to assess left ventricular volumes and mass. Cardiovascular risk factors (blood pressure, HDL/LDL cholesterol, smoking, body mass index) were assessed and coronary artery calcification (CAC) was quantified by electron beam computed tomography.
Left ventricular muscle mass (mean LVMM = 140 +/- 27 g; 73 +/- 13 g/m(2)) increased with increasing left ventricular end-diastolic volume (mean LVEDV = 137 +/- 32 ml; 72 +/- 15 ml/m(2)) (r = 0.41, P < 0.0001) and with systolic (r = 0.33, P = 0.005) and diastolic (r = 0.28, P = 0.005) blood pressures. Left ventricular EDV increased up to the age of 55 years, but decreased thereafter. Runners with LVMM > or =150 g had significantly higher CAC scores than runners with LVMM <150 g (median CAC score 110 vs. 25, P = 0.04).
Increases in LVMM and LVEDV may not only represent a response to exercise but are dependent on age and blood pressure, also. In addition, a left ventricular hypertrophy without an increase in volume may be an indicator for early subclinical cardiac alterations in response to risk factor exposure.
通过心脏磁共振成像评估年龄≥50岁的马拉松长跑健将的左心室容积和质量，并分析其与传统心血管危险因素及冠状动脉粥样硬化斑块负荷的关系。
对105名临床健康的男性马拉松长跑运动员（平均年龄57.3±5.7岁，年龄范围50 - 71岁）使用1.5T磁共振系统（德国西门子公司的Avanto）进行心脏磁共振成像检查。采集标准长轴和短轴视图的电影稳态自由进动图像，以评估左心室容积和质量。评估心血管危险因素（血压、高密度脂蛋白/低密度脂蛋白胆固醇、吸烟、体重指数），并通过电子束计算机断层扫描对冠状动脉钙化（CAC）进行定量分析。
左心室肌肉质量（平均左心室肌肉质量 = 140±27g；73±13g/m²）随着左心室舒张末期容积（平均左心室舒张末期容积 = 137±32ml；72±15ml/m²）的增加而增加（r = 0.41，P < 0.0001），且与收缩压（r = 0.33，P = 0.005）和舒张压（r = 0.28，P = 0.005）相关。左心室舒张末期容积在55岁之前增加，但此后下降。左心室肌肉质量≥150g的运动员的冠状动脉钙化评分显著高于左心室肌肉质量<150g的运动员（冠状动脉钙化评分中位数分别为110和25，P = 0.04）。
左心室肌肉质量和左心室舒张末期容积的增加不仅可能是对运动的反应，还取决于年龄和血压。此外，左心室肥厚但容积未增加可能是早期亚临床心脏改变以应对危险因素暴露的一个指标。
