乳腺纤维腺瘤中的染色体异常。

Chromosome abnormalities in breast fibroadenomas.

作者信息

Calabrese G, Di Virgilio C, Cianchetti E, Guanciali Franchi P, Stuppia L, Parruti G, Bianchi P G, Palka G

机构信息

Istituto di Biologia, Universitá di Chieti, Italy.

出版信息

Genes Chromosomes Cancer. 1991 May;3(3):202-4. doi: 10.1002/gcc.2870030305.

DOI:10.1002/gcc.2870030305

PMID:1868034

Abstract

A cytogenetic study on 25 breast fibroadenomas from 17 women is reported. Seven tumors in five patients showed clonal structural chromosome changes. In three patients the breaks involved chromosome 12, occurring in two tumors in band 12p12 and in band 12q15 in all three tumors of one patient. The finding of an identical aberration, t(11;12)(q21;q15), in three adenomas from the same patient strongly suggests a clonal origin of multiple fibroadenomas of the breast.

摘要

本文报道了对17名女性的25个乳腺纤维腺瘤进行的细胞遗传学研究。5名患者的7个肿瘤显示出克隆性染色体结构改变。3名患者的染色体断裂涉及12号染色体，其中2名患者的2个肿瘤断裂发生在12p12带，1名患者的所有3个肿瘤断裂发生在12q15带。同一患者的3个腺瘤中发现相同的畸变t(11;12)(q21;q15)，强烈提示乳腺多发性纤维腺瘤的克隆起源。