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动机性访谈对糖尿病风险的改善作用:一项随机对照试验

Motivational interviewing for modifying diabetes risk: a randomised controlled trial.

作者信息

Greaves Colin J, Middlebrooke Andrew, O'Loughlin Lucy, Holland Sandra, Piper Jane, Steele Anna, Gale Tracy, Hammerton Fenella, Daly Mark

机构信息

Peninsula Medical School, Exeter.

出版信息

Br J Gen Pract. 2008 Aug;58(553):535-40. doi: 10.3399/bjgp08X319648.

DOI:10.3399/bjgp08X319648
PMID:18682011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2566518/
Abstract

BACKGROUND

Around 10-15% of adults aged over 40 years have pre-diabetes, which carries a high risk of progression to type 2 diabetes. Intensive lifestyle intervention reduces progression by as much as 58%. However, the cost and personnel requirements of these interventions are major obstacles to delivery in NHS primary care.

AIM

To assess the effectiveness of a low-cost intervention, delivered in primary care by non-NHS staff, to reduce the risk of diabetes through weight loss and physical activity.

DESIGN OF STUDY

Pragmatic single-blind randomised controlled trial with researchers and statistician blinded to group allocation.

SETTING

UK primary care.

METHOD

One-hundred and forty-one participants with a body mass index of 28 kg/m2 or more, but without diabetes or heart disease, received either information leaflets or individual behavioural counselling using motivational interviewing techniques. The intervention was delivered by five counsellors recruited from the local community. The primary outcomes were the proportions of participants meeting predefined targets for weight loss (5%) and moderate physical activity (150 minutes/week) after 6 months.

RESULTS

Using intention-to-treat analysis, more people in the intervention group achieved the weight-loss target (24% versus 7% for controls; odds ratio [OR]=3.96; 95% confidence interval [Cl]=1.4 to 11.4; number needed to treat [NNT]=6.1 (95% Cl=4 to 21). The proportion achieving the physical activity target did not increase significantly (38% versus 28% for controls; OR=1.6; 95% Cl=0.7 to 3.8).

CONCLUSION

Short-term weight loss, at a level which, if sustained, is clinically meaningful for reducing diabetes risk, is achievable in primary care, without excessive use of NHS monetary or personnel resources.

摘要

背景

40岁以上的成年人中约有10%-15%患有糖尿病前期,其发展为2型糖尿病的风险很高。强化生活方式干预可将疾病进展风险降低多达58%。然而,这些干预措施的成本和人员需求是在英国国家医疗服务体系(NHS)基层医疗中实施的主要障碍。

目的

评估由非NHS工作人员在基层医疗中实施的低成本干预措施通过减肥和体育活动降低糖尿病风险的有效性。

研究设计

实用单盲随机对照试验,研究人员和统计人员对分组情况不知情。

研究地点

英国基层医疗。

方法

141名体重指数(BMI)为28kg/m²或更高但无糖尿病或心脏病的参与者,要么收到信息传单,要么接受使用动机性访谈技巧的个人行为咨询。干预由从当地社区招募的五名咨询师实施。主要结局是6个月后达到减肥(5%)和适度体育活动(每周150分钟)预定义目标的参与者比例。

结果

采用意向性分析,干预组中更多人实现了减肥目标(24%,对照组为7%;优势比[OR]=3.96;95%置信区间[CI]=1.4至11.4;需治疗人数[NNT]=6.1(95%CI=4至21))。达到体育活动目标的比例没有显著增加(38%,对照组为28%;OR=1.6;95%CI=0.7至3.8)。

结论

在基层医疗中可以实现短期内的体重减轻,如果能持续,这在临床上对降低糖尿病风险具有重要意义,且无需过度使用NHS的资金或人力资源。

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