Hofmann Alison, Burks A Wesley
Division of Pediatric Allergy and Immunology, Duke University Medical Center, DUMC Box 2898, Durham, NC 27110, USA.
Curr Allergy Asthma Rep. 2008 Sep;8(5):413-7. doi: 10.1007/s11882-008-0080-0.
Pollen food syndrome results from cross-reactivity between pollen-specific IgE and homologous proteins found in fruits and vegetables. These proteins can be grouped into several categories based on structure and include profilins, pathogenesis-related proteins, and cross-reactive carbohydrate determinants. Although cooking the reactive fruits and vegetables has been shown to destroy IgE-binding epitopes, evidence suggests that the remaining linear epitopes can bind cross-reactive T cells and enhance T-cell activation in vitro. Several methods of diagnosing food allergies exist, including skin prick tests and double-blind food challenges; however, diagnosing pollen food syndrome depends almost exclusively on clinical history. Immunotherapy has been studied as a treatment for pollen food syndrome, with highly variable results.
花粉食物综合征是由花粉特异性IgE与水果和蔬菜中发现的同源蛋白之间的交叉反应引起的。这些蛋白质可根据结构分为几类，包括肌动蛋白结合蛋白、病程相关蛋白和交叉反应性碳水化合物决定簇。虽然烹饪有反应的水果和蔬菜已被证明会破坏IgE结合表位，但有证据表明，剩余的线性表位可结合交叉反应性T细胞并在体外增强T细胞活化。存在多种诊断食物过敏的方法，包括皮肤点刺试验和双盲食物激发试验；然而，诊断花粉食物综合征几乎完全依赖于临床病史。免疫疗法已被研究作为花粉食物综合征的一种治疗方法，结果差异很大。
