Successful lung transplantation for talcosis secondary to intravenous abuse of oral drug.
作者信息
Shlomi Dekel, Shitrit David, Bendayan Daniele, Sahar Gidon, Shechtman Yitshak, Kramer Mordechai R
机构信息
Pulmonary Institute, Department of Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
出版信息
Int J Chron Obstruct Pulmon Dis. 2008;3(2):327-30. doi: 10.2147/copd.s2342.
Abstract
Talcosis due to intravenous injection of oral drugs can cause severe pulmonary disease with progressive dyspnea even when drug use is discontinued. We describe a 54-year-old woman with severe emphysema who underwent left lung transplantation. The patient had a remote history of intravenous injection of crushed methylphenidate (Ritalin) tablets. Chest computed tomography showed severe emphysematous changes, more prominent in the lower lobes. Microscopic examination of the extracted lung demonstrated multinucleated giant cells with birefringent crystals, compatible with talcosis. At follow-up, daily symptoms were completely alleviated and lung function was good. We recommend that lung transplantation be considered as a viable option in the treatment of talcosis.
摘要
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