Markus M Andrea, Morris Brian J
School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney, NSW, Australia.
Clin Interv Aging. 2008;3(2):331-9.
Resveratrol is a potent member of the class of natural, plant-derived chemicals known as polyphenols. These help explain in part why a diet high in fruit and vegetables confers health benefits and are associated with reduced risk of common complex conditions such as cardiovascular disease, cancer, diabetes, and Alzheimer's disease. We present the latest molecular findings that account for the beneficial actions of resveratrol. The intracellular pathways activated are crucial for anti-oxidant defence, regulation of the cell cycle, mitochondrial energy production, vascular tone, oncogene suppression, and many other phenomena which if unchecked lead to morbidity and mortality from onset and progression of these various diseases. While a healthy diet and lifestyle is strongly recommended in prevention of such conditions, the future bodes well for the use of resveratrol and analogues of higher potency than the natural form for treatment of diseases that afflict humans, particularly as they age.
白藜芦醇是一类名为多酚的天然植物衍生化学物质中的强效成分。这些物质部分解释了为何富含水果和蔬菜的饮食有益健康，且与降低患心血管疾病、癌症、糖尿病和阿尔茨海默病等常见复杂病症的风险相关。我们展示了最新的分子研究结果，这些结果解释了白藜芦醇的有益作用。所激活的细胞内信号通路对于抗氧化防御、细胞周期调控、线粒体能量产生、血管张力、癌基因抑制以及许多其他现象至关重要，而如果这些现象不受控制，就会导致这些各种疾病的发病和进展，进而引发发病和死亡。虽然强烈建议通过健康的饮食和生活方式来预防此类病症，但未来使用白藜芦醇及其比天然形式效力更高的类似物来治疗困扰人类的疾病前景良好，尤其是在人类衰老过程中。
