职业暴露与非霍奇金淋巴瘤：加拿大病例对照研究。
Occupational exposures and non-Hodgkin's lymphoma: Canadian case-control study.
作者信息
Karunanayake Chandima P, McDuffie Helen H, Dosman James A, Spinelli John J, Pahwa Punam
机构信息
Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, SK, Canada.
出版信息
Environ Health. 2008 Aug 7;7:44. doi: 10.1186/1476-069X-7-44.
BACKGROUND
The objective was to study the association between Non-Hodgkin's Lymphoma (NHL) and occupational exposures related to long held occupations among males in six provinces of Canada.
METHODS
A population based case-control study was conducted from 1991 to 1994. Males with newly diagnosed NHL (ICD-10) were stratified by province of residence and age group. A total of 513 incident cases and 1506 population based controls were included in the analysis. Conditional logistic regression was conducted to fit statistical models.
RESULTS
Based on conditional logistic regression modeling, the following factors independently increased the risk of NHL: farmer and machinist as long held occupations; constant exposure to diesel exhaust fumes; constant exposure to ionizing radiation (radium); and personal history of another cancer. Men who had worked for 20 years or more as farmer and machinist were the most likely to develop NHL.
CONCLUSION
An increased risk of developing NHL is associated with the following: long held occupations of faer and machinist; exposure to diesel fumes; and exposure to ionizing radiation (radium). The risk of NHL increased with the duration of employment as a farmer or machinist.
背景
目的是研究加拿大六个省份男性非霍奇金淋巴瘤（NHL）与长期从事的职业暴露之间的关联。
方法
1991年至1994年进行了一项基于人群的病例对照研究。新诊断为NHL（国际疾病分类第10版）的男性按居住省份和年龄组进行分层。分析共纳入513例新发病例和1506名基于人群的对照。进行条件逻辑回归以拟合统计模型。
结果
基于条件逻辑回归模型，以下因素独立增加了患NHL的风险：长期从事农民和机械师职业；持续接触柴油机废气；持续接触电离辐射（镭）；以及有其他癌症个人史。从事农民和机械师职业20年或更长时间的男性最有可能患NHL。
结论
患NHL风险增加与以下因素有关：长期从事农民和机械师职业；接触柴油机废气；以及接触电离辐射（镭）。患NHL的风险随着从事农民或机械师职业的时间延长而增加。
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