驱虫剂、苯氧基除草剂暴露与非霍奇金淋巴瘤
Insect repellents, phenoxyherbicide exposure, and non-Hodgkin's lymphoma.
作者信息
McDuffie Helen H, Pahwa Punam, Robson Diane, Dosman James A, Fincham Shirley, Spinelli John J, McLaughlin John R
机构信息
Institute of Agricultural Rural and Environmental Health, University of Saskatchewan, Saskatoon, SK, S7N 0W8, Canada.
出版信息
J Occup Environ Med. 2005 Aug;47(8):806-16. doi: 10.1097/01.jom.0000167260.80687.78.
OBJECTIVE
We sought to test a hypothetical explanation of contradictory results in studies of phenoxyherbicides and NHL, that the exposure of rubber gloves recommended for use by farmers when mixing or applying pesticides simultaneously to 2,4-D (2,4-dichlorophenoxyacetic acid), DEET (N,N-diethyl-m-toluamide), and ultraviolet rays increased their permeability to 2,4-D.
METHODS
We conducted a case (NHL n = 513)/control (n = 1506) study among men using age; province of residence; exposure to insect repellents containing DEET, phenoxy-herbicides, or dicamba; and gloves when handling pesticides.
RESULTS
Using conditional logistic regression, the stratum with reported exposure to mecoprop, to DEET and the use of rubber gloves had higher odds ratios (3.86; 95% confidence interval = 1.57-9.49) compared with strata with other combinations.
CONCLUSIONS
In conclusion, the etiologic complexity of NHL was demonstrated.
目的
我们试图检验一种关于苯氧基除草剂与非霍奇金淋巴瘤（NHL）研究中矛盾结果的假设性解释，即农民在混合或施用农药时推荐使用的橡胶手套同时接触2,4 - 二氯苯氧乙酸（2,4 - D）、避蚊胺（N,N - 二乙基 - m - 甲苯酰胺）和紫外线会增加其对2,4 - D的渗透性。
方法
我们在男性中开展了一项病例（NHL患者n = 513）/对照（n = 1506）研究，研究因素包括年龄、居住省份、接触含避蚊胺的驱虫剂、苯氧基除草剂或麦草畏以及处理农药时使用手套的情况。
结果
使用条件逻辑回归分析，报告接触麦草畏、避蚊胺且使用橡胶手套的分层与其他组合分层相比，比值比更高（3.86；95%置信区间 = 1.57 - 9.49）。
结论
总之，证明了NHL病因的复杂性。
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