职业暴露与霍奇金淋巴瘤：加拿大病例对照研究。
Occupational exposures and Hodgkin Lymphoma: Canadian case-control study.
机构信息
Canadian Centre for Health and Safety in Agriculture, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
出版信息
J Occup Environ Med. 2009 Dec;51(12):1447-54. doi: 10.1097/JOM.0b013e3181be6bfe.
OBJECTIVE
The objective was to study the association between Hodgkin Lymphoma (HL) and occupational exposures related to long-held occupation among males in Canada.
METHODS
A population-based case-control study of HL was conducted among males stratified by province of residence and age group. Conditional logistic regression was used to fit statistical models.
RESULTS
Several factors independently increased the risk of HL. Ever exposure to ionizing radiation from uranium showed a significant association with HL. Men who had smoked cigarettes for 25 years or more were the most likely to develop HL. Exposure to ultraviolet light and diagnosis with measles were negatively associated with HL, whereas diagnosis with shingles increased the risk of HL.
CONCLUSIONS
The higher risk of developing HL may be associated with exposure to uranium ionizing radiation and years of cigarette smoking.
目的
本研究旨在探讨加拿大男性霍奇金淋巴瘤（HL）与长期职业暴露之间的关系。
方法
采用基于人群的病例对照研究，对居住在不同省份和年龄组的男性 HL 患者进行研究。采用条件逻辑回归拟合统计模型。
结果
多项因素可独立增加 HL 的发病风险。曾接触铀产生的电离辐射与 HL 显著相关。吸烟 25 年或以上的男性最易患 HL。暴露于紫外线和麻疹诊断与 HL 呈负相关，而带状疱疹诊断则增加 HL 的发病风险。
结论
HL 的发病风险升高可能与接触铀电离辐射和吸烟年限有关。
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