Nahata M C
College of Pharmacy and Medicine, Ohio State University, Columbus 43210.
J Clin Pharm Ther. 1991 Jun;16(3):193-5. doi: 10.1111/j.1365-2710.1991.tb00303.x.
Comparative plasma concentrations of morphine in two children with chronic pain who received controlled-release and regular morphine sulphate tablets are described. The controlled-release tablets were given every 12 h and regular tablets every 4 h. At steady-state, the maximum morphine plasma concentration (Cmax) was 24.1 ng/ml at 45 mg and 18.7 ng/ml at 30 mg of controlled-release morphine sulphate tablets. The Cmax was 17.6 ng/ml at 15 mg and 31.4 ng/ml at 20 mg dose of the regular tablets. The maximum concentration occurred at 2.0 and 2.5 h after controlled-release and 0.25 and 1.5 h after regular tablets. The minimum morphine plasma concentrations and the area under the plasma concentration-time curve normalized for dose were comparable for the controlled-release and regular tablets. These data indicate that controlled-release morphine sulphate may be well absorbed in relation to the regular tablets. If these results are confirmed in a large group of patients, the controlled-release morphine sulphate tablets may offer a convenient (less frequent) dosing compared with regular tablets in children suffering from chronic pain due to malignancy.
描述了两名慢性疼痛儿童服用控释硫酸吗啡片和普通硫酸吗啡片后的血浆吗啡浓度比较情况。控释片每12小时服用一次，普通片每4小时服用一次。在稳态时，45毫克控释硫酸吗啡片的最大血浆吗啡浓度（Cmax）为24.1纳克/毫升，30毫克时为18.7纳克/毫升。普通片15毫克剂量时Cmax为17.6纳克/毫升，20毫克剂量时为31.4纳克/毫升。最大浓度出现在控释片服用后2.0和2.5小时以及普通片服用后0.25和1.5小时。控释片和普通片的最小血浆吗啡浓度以及按剂量归一化的血浆浓度-时间曲线下面积相当。这些数据表明，相对于普通片，控释硫酸吗啡可能吸收良好。如果这些结果在一大组患者中得到证实，对于因恶性肿瘤导致慢性疼痛的儿童，控释硫酸吗啡片可能比普通片提供更方便（给药频率更低）的给药方式。
