Vieira Sabas Carlos, Sousa Rodrigo Beserra, Tavares Marília Buenos Aires Cabral, de Abreu Benedita Andrade Leal, Ibiapina Jerúsia Oliveira, de Sousa Oliveira Alexandra Kolontai, Zeferino Luiz Carlos
Universidade Federal do Piauí (UFPI), Rua Félix Pacheco 2159, Sala 305, Edifício Shecap, 64001-160, Teresina, Piauí, Brazil.
Ann Surg Oncol. 2008 Oct;15(10):2862-6. doi: 10.1245/s10434-008-0089-6. Epub 2008 Aug 12.
To evaluate changes in pulse oximetry readings in patients with cervical carcinoma after the injection of patent blue dye into the uterine cervix for sentinel lymph node detection.
Fifty-six patients underwent radical hysterectomy and bilateral pelvic lymphadenectomy for the treatment of International Federation of Gynecology and Obstetrics stage I or II cervical cancer. Four milliliters of patent blue dye were injected into the cervix. On the eve of surgery, all patients also received an injection of Dextran 500 labeled with technetium 99 m (Tc-99 m Dextran, 600 to 800 muCi) into the cervix and subsequently underwent pelvic lymphoscintigraphy.
Of the 56 patients, 1 (1.79%) had an anaphylactic reaction, and in 13 (23.22%), pulse oximetry readings were <96%. The lowest median pulse oximetry reading in these patients was 87%. Pulse oximetry readings began to decrease between 2 and 10 minutes after patent blue dye injection into the cervix and lasted for approximately 5 minutes. No changes in blood pressure, heart rate, or electrocardiogram were found during the period in which this alteration was recorded by the pulse oximeter.
The decrease in pulse oximetry readings after patent blue dye injection into the cervix was associated with larger tumors and tumors that surrounded the external cervical os.
为评估在宫颈癌患者宫颈注射专利蓝染料以检测前哨淋巴结后脉搏血氧饱和度读数的变化。
56例因国际妇产科联盟（FIGO）I期或II期宫颈癌接受根治性子宫切除术和双侧盆腔淋巴结清扫术的患者。向宫颈注射4毫升专利蓝染料。在手术前夕，所有患者还接受了向宫颈注射99m锝标记的右旋糖酐500（99mTc-右旋糖酐，600至800μCi），随后进行盆腔淋巴闪烁显像。
56例患者中，1例（1.79%）发生过敏反应，13例（23.22%）脉搏血氧饱和度读数<96%。这些患者脉搏血氧饱和度读数的最低中位数为87%。脉搏血氧饱和度读数在宫颈注射专利蓝染料后2至10分钟开始下降，并持续约5分钟。在脉搏血氧仪记录到这种变化的期间，未发现血压、心率或心电图有变化。
宫颈注射专利蓝染料后脉搏血氧饱和度读数下降与较大肿瘤以及环绕宫颈外口的肿瘤有关。
