Lin Wenhan, Li Liya, Fu Hongzheng, Sattler Isabel, Huang Xueshi, Grabley Susanne
State Key Laboratories of Natural and Biomimetic Drugs, Beijing, 100083, P. R. China.
J Antibiot (Tokyo). 2005 Sep;58(9):594-8. doi: 10.1038/ja.2005.81.
From the mangrove plant Aegiceras comiculatum collected in South China an endophytic Streptomyces sp. was isolated. Following cultivation in a seawater-based medium, four new cyclopentenone derivatives, namely (5R) 3-amino-5-hydroxy-5-vinyl-2-cyclopenten-1-one (1), (5R) 5-hydroxy-3-[(methoxycarbonyl)amino]-5-vinyl-2-cyclopenten-1-one (2), (5R) 5-hydroxy-3-[[2-(4-hydroxyphenyl)ethyl]amino]-5-vinyl-2-cyclopenten-l-one (3), and 3-isobutylpropanamide-2-cyclopenten-l-one (4), were obtained from the fermentation broth. Their structures were elucidated by extensive spectroscopic (UV, IR, ESIMS, and 2D NMR) data analyses.
从中国南方采集的红树植物桐花树中分离出一株内生链霉菌。在以海水为基础的培养基中培养后，从发酵液中获得了四种新的环戊烯酮衍生物，即(5R)-3-氨基-5-羟基-5-乙烯基-2-环戊烯-1-酮(1)、(5R)-5-羟基-3-[(甲氧基羰基)氨基]-5-乙烯基-2-环戊烯-1-酮(2)、(5R)-5-羟基-3-[[2-(4-羟基苯基)乙基]氨基]-5-乙烯基-2-环戊烯-1-酮(3)和3-异丁基丙酰胺-2-环戊烯-1-酮(4)。通过广泛的光谱(紫外、红外、电喷雾离子质谱和二维核磁共振)数据分析确定了它们的结构。
