Lo J S, Snow S N, Reizner G T, Mohs F E, Larson P O, Hruza G J
Mohs Surgery Clinic, Department of Surgery, University of Wisconsin Hospital and Clinics, Madison 53705.
J Am Acad Dermatol. 1991 May;24(5 Pt 1):715-9. doi: 10.1016/0190-9622(91)70108-e.
Metastatic basal cell carcinoma was found in 12 patients at the University of Wisconsin Mohs Surgery Clinic during the period 1936 to 1989. All patients were white men. The time of onset of the primary tumor ranged from childhood to 71 years. Eleven patients had previous treatment for basal cell carcinoma; two patients had received x-ray radiation to the face for teenage acne. The locations of the primary basal cell carcinomas were the face (n = 10), back (n = 1), and arm (n = 1). The primary tumors ranged from 3.6 x 3.0 to 20.0 x 7.0 cm. The interval from onset to the first sign of metastases ranged from 7 to 34 years. In all cases, the primary tumor was histologically identical to the metastatic lesion. Perineural extension of the basal cell carcinoma in the primary lesion was found in five cases. Regional lymph nodes were the most frequent site of metastasis. Treatment consisted of a combination of surgery, radiation, and chemotherapy. Only two patients survived more than 5 years after surgical treatment. One patient has survived 25 years and is still alive.
1936年至1989年期间，威斯康星大学莫氏外科诊所发现了12例转移性基底细胞癌患者。所有患者均为白人男性。原发性肿瘤的发病时间从儿童期到71岁不等。11例患者曾接受过基底细胞癌治疗；2例患者因青少年痤疮接受过面部X线放射治疗。原发性基底细胞癌的部位为面部（n = 10）、背部（n = 1）和手臂（n = 1）。原发性肿瘤大小从3.6×3.0厘米到20.0×7.0厘米不等。从发病到出现转移的首个迹象的时间间隔为7至34年。在所有病例中，原发性肿瘤在组织学上与转移性病变相同。5例原发性病变中发现基底细胞癌有神经周围浸润。区域淋巴结是最常见的转移部位。治疗包括手术、放疗和化疗相结合。手术治疗后只有两名患者存活超过5年。一名患者已存活25年，仍在世。
