MYC的非转录功能：对翻译和DNA复制的调控
Transcription-independent functions of MYC: regulation of translation and DNA replication.
作者信息
Cole Michael D, Cowling Victoria H
机构信息
Department of Pharmacology, Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA.
出版信息
Nat Rev Mol Cell Biol. 2008 Oct;9(10):810-5. doi: 10.1038/nrm2467. Epub 2008 Aug 13.
Abstract
MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.
摘要
MYC是一种强大的致癌基因，可驱动细胞不受控制地生长和增殖。在被发现为致癌基因后不久，MYC蛋白就被认为是一种序列特异性转录因子。从那时起，MYC致癌基因的研究就集中在MYC诱导转录的机制以及MYC转录靶基因的鉴定上。最近，MYC被证明可通过mRNA翻译来控制蛋白质表达，并直接调节DNA复制，从而开启了致癌基因研究令人兴奋的新领域。
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