科迪纳菌素，一种抗疟真菌聚酮化合物。
Codinaeopsin, an antimalarial fungal polyketide.
作者信息
Kontnik Renee, Clardy Jon
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Org Lett. 2008 Sep 18;10(18):4149-51. doi: 10.1021/ol801726k. Epub 2008 Aug 13.
Abstract
A new tryptophan-polyketide hybrid, codinaeopsin, was isolated from an endophytic fungus collected in Costa Rica. The structure of codinaeopsin, which was deduced from NMR and mass spectral data, contains an unusual heterocyclic unit linking indole and decalin fragments. Codinaeopsin is active against Plasmodium falciparum, the causative agent of the most lethal form of malaria (IC50 = 2.3 microg/mL or 4.7 microM).
摘要
从在哥斯达黎加采集的一种内生真菌中分离出一种新的色氨酸-聚酮化合物杂合体——可地纳菌素。通过核磁共振和质谱数据推导得出的可地纳菌素结构包含一个连接吲哚和十氢化萘片段的不寻常杂环单元。可地纳菌素对最致命形式疟疾的病原体恶性疟原虫具有活性（半数抑制浓度IC50 = 2.3微克/毫升或4.7微摩尔）。
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