气道压力变化对人鼻温暖和湿润空气能力的影响。
Effect of changing airway pressure on the ability of the human nose to warm and humidify air.
作者信息
Sahin-Yilmaz Asli, Baroody Fuad M, DeTineo Marcy, Cuttance Georgina, Makinson Doug, Pinto Jayant M, Naureckas Edward T, Naclerio Robert M
机构信息
Department of Surgery, Section of Otolaryngology-Head and Neck Surgery, University of Chicago, Chicago, Illinois 60637, USA.
出版信息
Ann Otol Rhinol Laryngol. 2008 Jul;117(7):501-5. doi: 10.1177/000348940811700705.
OBJECTIVES
Nasal continuous positive airway pressure (CPAP) treatment causes nasal symptoms that are believed to result from the drying effects of the air on the nasal mucosa, and these symptoms affect compliance with therapy. We hypothesized that the increased air pressure on the nasal mucosa caused by positive pressure from CPAP would decrease the ability of the nose to warm and humidify inspired air, explaining these symptoms.
METHODS
We performed a 4-way crossover trial using CPAP pressures of -5, 0, +5, and +10 cm H2O in 10 subjects. The ability to warm and humidify inspired air was determined by measurement of the temperature of a fixed volume of cold, dry air entering and exiting the nostril and calculation of the amount of water supplied to the airstream by the nose.
RESULTS
The water content of air was unaffected at the pressures studied.
CONCLUSIONS
The pressure of delivered CPAP does not affect the ability of the nose to warm and humidify inspired air.
目的
鼻持续气道正压通气（CPAP）治疗会引发鼻部症状，据信这是空气对鼻黏膜的干燥作用所致，且这些症状会影响治疗的依从性。我们推测，CPAP产生的正压作用于鼻黏膜所导致的气压升高，会降低鼻腔对吸入空气进行加热和加湿的能力，从而解释了这些症状。
方法
我们对10名受试者进行了一项四路交叉试验，使用-5、0、+5和+10厘米水柱的CPAP压力。通过测量固定体积的冷干空气进入和离开鼻孔时的温度，并计算鼻腔向气流中供应的水量，来确定鼻腔对吸入空气进行加热和加湿的能力。
结果
在所研究的压力下，空气的含水量未受影响。
结论
所输送的CPAP压力并不影响鼻腔对吸入空气进行加热和加湿的能力。
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