Furuuchi S, Shimizu Y, Kumagai T
Am J Vet Res. 1976 Dec;37(12):1401-4.
Clinical signs of transmissible gastroenteritis were not observed in newborn pigs orally inoculated with the high-passaged vaccinal transmissible gastroenteritis virus (TO-163 strain). Vaccinal viral multiplication in digestive tract of newborn pigs fed colostrum before inoculation and kept at 21 to 22 C was diminished, but was not diminished in those fed colostrum and kept at 10 to 11 C. Other groups of newborn pigs inoculated with the attenuated vaccinal virus and kept at 18 to 22 C or at 31 to 34 C were challenge exposed with virulent intestinal virus on the 1st, 2nd, . . ., or 6th postinoculation (PI) days. In the groups kept at 18 to 22 C, 2 of 7 inoculated pigs challenge exposed with virulent virus on the 3rd PI day, 4 of 7 pigs exposed on the 4th PI day, and all of the pigs exposed on and after the 5th PI day survived the exposure. In the groups kept at 18 to 22 C, the attenuated vaccinal virus was distributed mainly in the respiratory organs and lymphatic tissues. On the contrary, in the groups kept at 31 to 34 C, all of the pigs died in 2 to 5 days after challenge exposure, and the attenuated vaccinal virus was scarcely detected in any of the pigs.
给新生仔猪口服高传代的疫苗性传染性胃肠炎病毒（TO - 163株）后，未观察到传染性胃肠炎的临床症状。在接种前喂初乳并饲养在21至22摄氏度的新生仔猪消化道中，疫苗病毒的增殖减少，但在喂初乳并饲养在10至11摄氏度的仔猪中并未减少。其他接种减毒疫苗病毒并饲养在18至22摄氏度或31至34摄氏度的新生仔猪组，在接种后第1、2、……或6天用强毒肠道病毒进行攻毒。在饲养于18至22摄氏度的组中，在接种后第3天接受强毒病毒攻毒的7头接种仔猪中有2头存活，在第4天攻毒的7头仔猪中有4头存活，在第5天及以后攻毒的所有仔猪均存活。在饲养于18至22摄氏度的组中，减毒疫苗病毒主要分布在呼吸器官和淋巴组织中。相反，在饲养于31至34摄氏度的组中，所有仔猪在攻毒后2至5天死亡，且在任何仔猪中几乎都检测不到减毒疫苗病毒。
