Yu Bing, Fu Henry, Bydlon Torre, Bender Janelle E, Ramanujam Nirmala
Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Opt Lett. 2008 Aug 15;33(16):1783-5. doi: 10.1364/ol.33.001783.
Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/-7.2% and 3.5%+/-1.5%, respectively.
针对仪器响应、随时间变化的波动以及设备间差异对漫反射光谱进行校准既复杂、耗时，又可能不准确。我们描述了一种具有实时自校准能力的新型光纤探头，可用于组织光学光谱分析。该探头在一系列具有相关组织光学特性的液体模型中进行了测试。提取的吸收系数和散射系数的平均绝对误差和标准偏差分别为6.9%±7.2%和3.5%±1.5%。
