Arifler Dizem, Schwarz Richard A, Chang Sung K, Richards-Kortum Rebecca
Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
Appl Opt. 2005 Jul 10;44(20):4291-305. doi: 10.1364/ao.44.004291.
Reflectance spectroscopy is a promising technology for detection of epithelial precancer. Fiber-optic probes that selectively collect scattered light from both the epithelium and the underlying stroma are likely to improve diagnostic performance of in vivo reflectance spectroscopy by revealing diagnostic features unique to each layer. We present Monte Carlo models with which to evaluate fiber-optic probe geometries with respect to sampling depth and depth resolution. We propose a probe design that utilizes half-ball lens coupled source and detector fibers to isolate epithelial scattering from stromal scattering and hence to resolve spectral information from the two layers. The probe is extremely compact and can provide easy access to different organ sites.
反射光谱技术是一种很有前景的上皮癌前病变检测技术。能够选择性地收集来自上皮组织和其下方基质散射光的光纤探头，通过揭示各层独特的诊断特征，有望提高体内反射光谱技术的诊断性能。我们提出了蒙特卡洛模型，用于评估光纤探头几何结构在采样深度和深度分辨率方面的性能。我们设计了一种探头，该探头利用半球透镜耦合源光纤和探测器光纤，以分离上皮组织散射和基质散射，从而解析两层的光谱信息。该探头极为紧凑，能够方便地检测不同的器官部位。
