Cormode David P, Briley-Saebo Karen C, Mulder Willem J M, Aguinaldo Juan Gilberto S, Barazza Alessandra, Ma Yanqing, Fisher Edward A, Fayad Zahi A
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place Box 1234, New York, NY 10029, USA.
Small. 2008 Sep;4(9):1437-44. doi: 10.1002/smll.200701285.
Cardiovascular disease is one of the prime causes of mortality throughout the world and there is a need for targeted and effective contrast agents to allow noninvasive imaging of the cholesterol-rich atherosclerotic plaques in arteries. A new, fully synthetic, high-density lipoprotein (HDL)-mimicking MRI contrast agent is developed, which enhances macrophage-rich areas of plaque in a mouse model of atherosclerosis by 94%. Confirmation of the targeting of this nanoparticulate agent is achieved using confocal microscopy by tracking a fluorescent lipid incorporated into the nanoparticle.
心血管疾病是全球主要的死亡原因之一，因此需要有针对性的有效造影剂，以便对动脉中富含胆固醇的动脉粥样硬化斑块进行无创成像。一种新型的、完全合成的、模仿高密度脂蛋白（HDL）的磁共振成像（MRI）造影剂被研发出来，在动脉粥样硬化小鼠模型中，它可使斑块中富含巨噬细胞的区域增强94%。通过追踪掺入纳米颗粒中的荧光脂质，利用共聚焦显微镜实现了对这种纳米颗粒剂靶向性的确认。
