Chen Jun, Zhang Xixi, Millican Reid, Creutzmann Jacob Emil, Martin Sean, Jun Ho-Wook
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Nano Converg. 2020 Jan 27;7(1):6. doi: 10.1186/s40580-019-0214-1.
Atherosclerosis is a major contributor to many cardiovascular events, including myocardial infarction, ischemic stroke, and peripheral arterial disease, making it the leading cause of death worldwide. High-density lipoproteins (HDL), also known as "good cholesterol", have been shown to demonstrate anti-atherosclerotic efficacy through the removal of cholesterol from foam cells in atherosclerotic plaques. Because of the excellent anti-atherosclerotic properties of HDL, in the past several years, there has been tremendous attention in designing HDL mimicking nanoparticles (NPs) of varying functions to image, target, and treat atherosclerosis. In this review, we are summarizing the recent progress in the development of HDL mimicking NPs and their applications for atherosclerosis.
动脉粥样硬化是导致许多心血管事件的主要因素，包括心肌梗死、缺血性中风和外周动脉疾病，使其成为全球主要死因。高密度脂蛋白（HDL），也被称为“好胆固醇”，已被证明可通过从动脉粥样硬化斑块中的泡沫细胞中清除胆固醇来发挥抗动脉粥样硬化作用。由于HDL具有出色的抗动脉粥样硬化特性，在过去几年中，设计具有不同功能的HDL模拟纳米颗粒（NPs）用于成像、靶向和治疗动脉粥样硬化受到了极大关注。在这篇综述中，我们总结了HDL模拟NPs的开发及其在动脉粥样硬化中的应用的最新进展。
