天门冬的生物活性成分。

Bioactive constituents from Asparagus cochinchinensis.

作者信息

Zhang Hong-Jie, Sydara Kongmany, Tan Ghee Teng, Ma Cuiying, Southavong Bounhoong, Soejarto D Doel, Pezzuto John M, Fong Harry H S

机构信息

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy (M/C877), College of Pharmacy, the University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.

出版信息

J Nat Prod. 2004 Feb;67(2):194-200. doi: 10.1021/np030370b.

DOI:10.1021/np030370b

PMID:14987058

Abstract

Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3' '-methoxyasparenydiol (4), and a new polyphenol, 3'-hydroxy-4'-methoxy-4'-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3' '-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC(50) values ranging from 4 to 12 microg/mL. The structures were determined by spectroscopic and chemical methods.

摘要

对天门冬干燥根进行生物活性导向的分离，得到一种新的螺旋甾烷醇皂苷——天门冬苷（1）、两种新的C-27螺旋甾醇——天门冬素A（2）和B（3）、一种新的炔衍生物——3''-甲氧基天门冬二醇（4）、一种新的多酚——3'-羟基-4'-甲氧基-4'-脱羟基尼亚索（6），以及五种已知的酚类化合物——天门冬二醇（5）、尼亚索（7）、3''-甲氧基尼亚索（8）、1,3-双-对羟基苯基-4-戊烯-1-酮（9）和反式松柏醇（10）。化合物1、6和8在由KB、Col-2、LNCaP、Lu-1和HUVEC细胞组成的细胞系中表现出中等细胞毒性，IC(50)值在4至12μg/mL之间。通过光谱和化学方法确定了其结构。