DeBrosse Charles W, Rothenberg Marc E
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Curr Opin Immunol. 2008 Dec;20(6):703-8. doi: 10.1016/j.coi.2008.07.010. Epub 2008 Sep 11.
Eosinophil-associated gastrointestinal disorders (EGIDs) are characterized by an inappropriate accumulation of eosinophils within the gastrointestinal tract. The underlying etiology and pathophysiology that lead to the development of EGID are far from elucidated. However, there is growing evidence to support the role of aeroallergens and food allergens in the pathogenesis of these disorders. Recent advances have highlighted the role of Th2-driven cytokines in the development of EGID, and clinical studies have verified that children and adults with EGID often have positive skin testing to food allergens. The most common form of EGID, eosinophilic esophagitis (EE), has garnered intense investigation following an increased recognition over the past decade. Recently, there have been several important studies providing insight into both the cellular mechanisms governing EE and clinical therapies directed toward the treatment of EE. In the article herein, we will review the most recent scientific advances influencing our understanding of EGID with special emphasis on the role of allergens in the pathogenesis of EGID.
嗜酸性粒细胞相关的胃肠道疾病（EGIDs）的特征是胃肠道内嗜酸性粒细胞异常积聚。导致EGID发生的潜在病因和病理生理学尚未完全阐明。然而，越来越多的证据支持空气过敏原和食物过敏原在这些疾病发病机制中的作用。最近的进展突出了Th2驱动的细胞因子在EGID发展中的作用，临床研究证实，患有EGID的儿童和成人对食物过敏原的皮肤试验通常呈阳性。EGID最常见的形式是嗜酸性粒细胞性食管炎（EE），在过去十年中，随着认识的提高，它受到了广泛的研究。最近，有几项重要研究为控制EE的细胞机制和针对EE治疗的临床疗法提供了见解。在本文中，我们将回顾影响我们对EGID理解的最新科学进展，特别强调过敏原在EGID发病机制中的作用。
