AMIN结构域在多种周质蛋白复合物的定位中具有预测作用。
AMIN domains have a predicted role in localization of diverse periplasmic protein complexes.
作者信息
de Souza Robson Francisco, Anantharaman Vivek, de Souza Sandro José, Aravind L, Gueiros-Filho Frederico J
机构信息
Departamento de Bioquímica, Universidade de São Paulo, São Paulo, Brazil.
出版信息
Bioinformatics. 2008 Nov 1;24(21):2423-6. doi: 10.1093/bioinformatics/btn449. Epub 2008 Aug 21.
We describe AMIN (Amidase N-terminal domain), a novel protein domain found specifically in bacterial periplasmic proteins. AMIN domains are widely distributed among peptidoglycan hydrolases and transporter protein families. Based on experimental data, contextual information and phyletic profiles, we suggest that AMIN domains mediate the targeting of periplasmic or extracellular proteins to specific regions of the bacterial envelope.
我们描述了AMIN（酰胺酶N端结构域），这是一种在细菌周质蛋白中特有的新型蛋白质结构域。AMIN结构域广泛分布于肽聚糖水解酶和转运蛋白家族中。基于实验数据、背景信息和系统发育谱，我们认为AMIN结构域介导周质或细胞外蛋白靶向细菌包膜的特定区域。
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