Pirooznia Mehdi, Habib Tanwir, Perkins Edward J, Deng Youping
Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Bioinformatics. 2008 Nov 1;24(21):2561-3. doi: 10.1093/bioinformatics/btn441. Epub 2008 Aug 26.
An important contribution to the Gene Ontology (GO) project is to develop tools that facilitate the creation, maintenance and use of ontologies. Several tools have been created for communicating and using the GO project. However, a limitation with most of these tools is that they suffer from lack of a comprehensive search facility. We developed a web application, GOfetcher, with a very comprehensive search facility for the GO project and a variety of output formats for the results. GOfetcher has three different levels for searching the GO: 'Quick Search', 'Advanced Search' and 'Upload Files' for searching. The application includes a unique search option which generates gene information given a nucleotide or protein accession number which can then be used in generating GO information. The output data in GOfetcher can be saved into several different formats; including spreadsheet, comma-separated values and the extensible markup language (XML) format. The database is available at http://mcbc.usm.edu/gofetcher/.
对基因本体论(GO)项目的一项重要贡献是开发便于本体创建、维护和使用的工具。已经创建了几个用于交流和使用GO项目的工具。然而,这些工具大多存在一个局限性,即缺乏全面的搜索功能。我们开发了一个网络应用程序GOfetcher,它为GO项目提供了非常全面的搜索功能,并为结果提供了多种输出格式。GOfetcher有三个不同层次来搜索GO:“快速搜索”、“高级搜索”和“上传文件”进行搜索。该应用程序包括一个独特的搜索选项,给定一个核苷酸或蛋白质登录号就能生成基因信息,然后可用于生成GO信息。GOfetcher中的输出数据可以保存为几种不同格式,包括电子表格、逗号分隔值和可扩展标记语言(XML)格式。该数据库可在http://mcbc.usm.edu/gofetcher/获取。