Takatani O, Okumoto T, Kosano H
Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Breast Cancer Res Treat. 1991 May;18 Suppl 1:S27-9. doi: 10.1007/BF02633523.
We investigated changes in the amount of sex hormone binding globulin (SHBG) and the percentage of free estradiol (% FE2) during normal menstrual cycles in the sera of 8 young Japanese controls, and also the relation between the lipid components of serum and the serum level of SHBG in 250 normal Japanese controls aged 18-77 years. The amount of SHBG measured by IRMA was significantly higher in the luteal phase than in the follicular phase, whereas the % FE2 values remained constant throughout the menstrual cycle in 8 healthy young controls. These results suggest that the estrogen status in serum is constantly controlled by SHBG. The amount of SHBG was significantly correlated with the serum level of triglycerides (TG) in 250 normal Japanese controls. From these results, we postulate that the decrease in serum SHBG, probably caused by increased level of serum TG, leads to elevation of % FE2 and later to a status with a high risk of breast cancer.
我们调查了8名年轻日本对照者血清中在正常月经周期中性激素结合球蛋白（SHBG）量和游离雌二醇百分比（%FE2）的变化，还研究了250名年龄在18至77岁的正常日本对照者血清脂质成分与血清SHBG水平之间的关系。通过免疫放射分析（IRMA）测定的SHBG量在黄体期显著高于卵泡期，而在8名健康年轻对照者中，%FE2值在整个月经周期中保持恒定。这些结果表明，血清中的雌激素状态受SHBG持续调控。在250名正常日本对照者中，SHBG量与血清甘油三酯（TG）水平显著相关。基于这些结果，我们推测血清SHBG的降低可能是由血清TG水平升高引起的，这会导致%FE2升高，进而导致患乳腺癌风险增加的状态。
