Nagata C, Kaneda N, Kabuto M, Shimizu H
Department of Public Health, Gifu University School of Medicine, Gifu, Japan.
Environ Health Perspect. 1997 Sep;105(9):994-7. doi: 10.1289/ehp.97105994.
We measured serum levels of estradiol (E(2)) and sex hormone-binding globulin (SHBG) among 50 healthy premenopausal Japanese women in 1994 in Gifu, Japan, to investigate the relationships between potential risk factors for breast cancer and hormone levels. Using a self-administered questionnaire, we collected data on body size, physical activity, and previous disease history, as well as menstrual and reproductive histories of the woman and her mother. Blood samples were drawn from each subject on the 11th and 22nd days of her menstrual cycle. Higher serum E(2) levels were observed for women with shorter menstrual cycles. Age as well as cycle length were included in the regression models to determine the associations between hormone levels and study variables. Body mass index (BMI) was inversely related to SHBG level measured at the 11th day of the cycle, after adjusting for age and cycle length (r = -0.33; p = 0. 03). Women born in spring/summer had higher levels of E(2) on the 22nd day (p = 0.07) and higher levels of SHBG on both the 11th and 22nd days of the cycle (p = 0.01 and p = 0.06, respectively) than those born in other seasons. Physical activity at 13-15 years of age was inversely related to E(2) level on the 11th day of the cycle after controlling for age, cycle length, BMI, and birth month (r = -0.35; p = 0.04).
1994年，我们在日本岐阜对50名健康的绝经前日本女性测量了血清雌二醇（E₂）和性激素结合球蛋白（SHBG）水平，以研究乳腺癌潜在风险因素与激素水平之间的关系。我们通过一份自填式问卷收集了有关身体尺寸、身体活动和既往病史的数据，以及该女性及其母亲的月经和生育史。在月经周期的第11天和第22天从每个受试者采集血样。月经周期较短的女性血清E₂水平较高。年龄以及周期长度被纳入回归模型以确定激素水平与研究变量之间的关联。在调整年龄和周期长度后，体重指数（BMI）与周期第11天测量的SHBG水平呈负相关（r = -0.33；p = 0.03）。与出生在其他季节的女性相比，出生在春季/夏季的女性在第22天的E₂水平较高（p = 0.07），在周期的第11天和第22天的SHBG水平也较高（分别为p = 0.01和p = 0.06）。在控制年龄、周期长度、BMI和出生月份后，13 - 15岁时的身体活动与周期第11天的E₂水平呈负相关（r = -0.35；p = 0.04）。
