Hoffman D A, Wallace S M, Verbeeck R K
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
J Chromatogr. 1991 Apr 19;565(1-2):447-52. doi: 10.1016/0378-4347(91)80408-5.
A single-column ion chromatographic assay with conductivity detection was developed to determine inorganic sulfate concentrations in human plasma and urine samples. Plasma samples were ultrafiltered to remove proteins. Plasma ultrafiltrate and urine samples were diluted prior to injection onto the anion-exchange column. The described method is simple, fast, sensitive and reproducible and was used to study the effect of subchronic administration of acetaminophen on the plasma concentrations and urinary excretion of inorganic sulfate in healthy volunteers.
建立了一种带电导检测的单柱离子色谱分析法，用于测定人血浆和尿液样本中的无机硫酸盐浓度。血浆样本经超滤以去除蛋白质。血浆超滤物和尿液样本在注入阴离子交换柱之前进行稀释。所描述的方法简单、快速、灵敏且可重复，用于研究对乙酰氨基酚亚慢性给药对健康志愿者血浆中无机硫酸盐浓度和尿排泄的影响。
