Verotta D, Sheiner L B, Beal S L
Department of Laboratory Medicine, School of Medicine, University of California San Francisco 94143-0626.
J Pharmacokinet Biopharm. 1991 Jun;19(3):319-31. doi: 10.1007/BF03036254.
This note gives expressions for recirculation mean time parameters of the disposition kinetics of particles in a semihomogeneous stationary linear system. In such a system each compartment may have an arbitrary single-pass disposition function, rather than a known parametric (usually monoexponential) one. Such systems provide a generalization of physiological flow models. Given observations of arterial blood concentrations and tissue amounts, and making the additional assumptions that (i) the fraction of total blood flow exiting each tissue that goes to each other tissue is constant and known, and (ii) the fraction of drug entering each tissue that is eliminated to the outside is constant and known, the input to each tissue can be known, and therefore both its total blood flow and its single-pass disposition function can be estimated. Recirculation mean time parameters can be computed from these estimates. Application to real thiopental data is presented as an example.
本笔记给出了半均匀稳态线性系统中粒子处置动力学再循环平均时间参数的表达式。在这样的系统中，每个隔室可以具有任意的单通道处置函数，而不是已知的参数化（通常是单指数）函数。此类系统是生理流动模型的推广。给定动脉血浓度和组织量的观测值，并做出额外假设：（i）离开每个组织并流向其他每个组织的总血流量的分数是恒定且已知的；（ii）进入每个组织的药物中被消除到外部的分数是恒定且已知的，那么每个组织的输入就可以确定，因此其总血流量及其单通道处置函数都可以估算出来。再循环平均时间参数可以根据这些估算值计算得出。作为示例，给出了其在实际硫喷妥数据中的应用。
