银纳米颗粒对皮肤癣菌的抗真菌作用。

Antifungal effect of silver nanoparticles on dermatophytes.

作者信息

Kim Keuk-Jun, Sung Woo Sang, Moon Seok-Ki, Choi Jong-Soo, Kim Jong Guk, Lee Dong Gun

机构信息

Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.

出版信息

J Microbiol Biotechnol. 2008 Aug;18(8):1482-4.

DOI:

PMID:18756112

Abstract

Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

摘要

合成了球形银纳米颗粒（纳米银），并研究了其对皮肤真菌病原体的抗真菌作用。纳米银对须癣毛癣菌和念珠菌属的临床分离株及美国典型培养物保藏中心（ATCC）菌株显示出强效活性（IC80，1 - 7微克/毫升）。纳米银的活性与两性霉素B相当，但优于氟康唑（两性霉素B的IC80，1 - 5微克/毫升；氟康唑的IC80，10 - 30微克/毫升）。此外，我们研究了它们对白色念珠菌双态性的影响。结果表明纳米银对菌丝体有活性。因此，本研究表明纳米银可能具有相当大的抗真菌活性，值得进一步研究以用于临床应用。