Slavin Yael N, Bach Horacio
Department of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak St., Vancouver, BC V6H3Z6, Canada.
Nanomaterials (Basel). 2022 Dec 16;12(24):4470. doi: 10.3390/nano12244470.
The appearance of resistant species of fungi to the existent antimycotics is challenging for the scientific community. One emergent technology is the application of nanotechnology to develop novel antifungal agents. Metal nanoparticles (NPs) have shown promising results as an alternative to classical antimycotics. This review summarizes and discusses the antifungal mechanisms of metal NPs, including combinations with other antimycotics, covering the period from 2005 to 2022. These mechanisms include but are not limited to the generation of toxic oxygen species and their cellular target, the effect of the cell wall damage and the hyphae and spores, and the mechanisms of defense implied by the fungal cell. Lastly, a description of the impact of NPs on the transcriptomic and proteomic profiles is discussed.
真菌耐药菌株的出现对科学界构成了挑战。一种新兴技术是应用纳米技术开发新型抗真菌剂。金属纳米颗粒（NPs）作为传统抗真菌剂的替代品已显示出有前景的结果。本综述总结并讨论了2005年至2022年期间金属纳米颗粒的抗真菌机制，包括与其他抗真菌剂的联合使用。这些机制包括但不限于有毒氧物种的产生及其细胞靶点、细胞壁损伤以及对菌丝和孢子的影响，以及真菌细胞所涉及的防御机制。最后，讨论了纳米颗粒对转录组和蛋白质组图谱的影响。
