Bayliss Elizabeth A, Ellis Jennifer L, Steiner John F
Institute for Health Research, Kaiser Permanente, Denver, CO 80237-8066, USA.
J Clin Epidemiol. 2009 May;62(5):550-7.e1. doi: 10.1016/j.jclinepi.2008.05.002. Epub 2008 Aug 30.
To explore the constructs underlying a self-report assessment of multimorbidity.
We conducted a cross-sectional survey of 352 HMO members aged 65 years or more with, at a minimum, diabetes, depression, and osteoarthritis. We assessed self-reported 'disease burden' (a severity-adjusted count of conditions) as a function of biopsychosocial factors, two data-based comorbidity indices, and demographic variables.
In multivariate regression, age, 'compound effects of conditions' (treatments and symptoms interfering with each other), self-efficacy, financial constraints, and physical functioning were significantly (p<or=0.05) associated with disease burden. An ICD-9-based morbidity index did not significantly contribute to disease burden, and a pharmacy-data-based morbidity index was minimally significant.
This measure of self-reported disease burden represents an amalgamation of functional capabilities, social considerations, and medical conditions that are not captured by two administrative data-based measures of morbidity. This suggests that (a) self-reported descriptions of multimorbidity incorporate biopsychosocial constructs that reflect the perceived burden of multimorbidity, (b) a simple count of diagnoses should be supplemented by an assessment of activity limitations imposed by these conditions, and (c) choice of the morbidity measurement instrument should be based on the outcome of interest rather than on the most convenient method of measurement.
探究多重疾病自我报告评估背后的构成要素。
我们对352名65岁及以上的健康维护组织(HMO)成员进行了横断面调查,这些成员至少患有糖尿病、抑郁症和骨关节炎。我们评估了自我报告的“疾病负担”(一种经严重程度调整的疾病计数),将其作为生物心理社会因素、两个基于数据的共病指数以及人口统计学变量的函数。
在多变量回归分析中,年龄、“疾病复合效应”(治疗和症状相互干扰)、自我效能感、经济限制和身体功能与疾病负担显著相关(p≤0.05)。基于国际疾病分类第九版(ICD - 9)的发病率指数对疾病负担的贡献不显著,而基于药房数据的发病率指数仅有微弱的显著性。
这种自我报告的疾病负担衡量方法代表了功能能力、社会因素和医疗状况的综合,而这是两种基于管理数据的发病率衡量方法所无法涵盖的。这表明:(a)多重疾病的自我报告描述纳入了反映多重疾病感知负担的生物心理社会构成要素;(b)对诊断的简单计数应辅以对这些疾病所造成的活动限制的评估;(c)发病率测量工具的选择应基于感兴趣的结果,而非最便捷的测量方法。