较低的环境温度：长期暴露对大脑γ-氨基丁酸（GABA）中地西泮诱导变化的影响。

Lower environmental temperature: effect of long-term exposure on diazepam-induced changes in brain GABA.

作者信息

Biswas S, Mukhopadhyay S, Poddar M K

机构信息

Department of Biochemistry, University College of Science, University of Calcutta, India.

出版信息

Methods Find Exp Clin Pharmacol. 1991 May;13(4):255-61.

PMID:1875774

Abstract

Long-term diazepam (DZ) treatment (5 mg/kg, i.p. for 15-30 consecutive days) reduced GABAergic activity in hypothalamus and cerebellum with the alteration of GABA synthesis and its release process. This long-term DZ-induced inhibition in GABAergic activity in hypothalamus and cerebellum was not altered when DZ-treated rats were exposed (2 h/day) to lower environmental temperature (LET; 12 degrees C) for 7-30 consecutive days. Although repeated exposure to LET did not affect the GABA system in cerebellum and hypothalamus, striatal GABAergic activity was significantly enhanced under similar conditions. This LET-induced (repeated exposure) stimulation in striatal GABAergic activity was prevented when rats were treated with DZ along with repeated LET exposure (2 h/day) under long-term conditions.

摘要

长期给予地西泮（DZ）治疗（5毫克/千克，腹腔注射，连续15 - 30天）会降低下丘脑和小脑的γ-氨基丁酸（GABA）能活性，并改变GABA的合成及其释放过程。当接受DZ治疗的大鼠连续7 - 30天每天暴露（2小时）于较低环境温度（LET；12摄氏度）时，这种长期由DZ诱导的下丘脑和小脑GABA能活性抑制并未改变。尽管反复暴露于LET对小脑和下丘脑的GABA系统没有影响，但在类似条件下纹状体GABA能活性显著增强。当大鼠在长期条件下接受DZ治疗并同时反复暴露于LET（每天2小时）时，这种LET诱导的（反复暴露）纹状体GABA能活性刺激被阻止。