Biswas S, Poddar M K
Department of Biochemistry, University College of Science, University of Calcutta, India.
Methods Find Exp Clin Pharmacol. 1990 Jul-Aug;12(6):395-400.
The effects of repeated exposure (2 h/day) to high environmental temperatures (40 degrees C) for 7, 15 and 30 consecutive days on gamma-aminobutyric acid (GABA) metabolism in different regions of adult rat brain were investigated. The GABAergic activity in hypothalamus was increased with the increase in duration (7-30 days) of HET exposure. In corpus striatum, on the other hand, 7 days repeated HET-induced increase in GABAergic activity was attenuated on prolongation of HET exposure from 15-30 consecutive days. Repeated HET exposure for 7 consecutive days also enhanced cerebrocortical GABAergic activity that became normalized following 15 or 30 days repeated HET exposure. These results suggest that long-term (repeated HET exposure enhanced hypothalamic GABAergic activity to adapt to the environment with the regulation of body temperature.
研究了成年大鼠连续7天、15天和30天每天2小时重复暴露于高温环境（40摄氏度）对其大脑不同区域γ-氨基丁酸（GABA）代谢的影响。随着高温暴露时间（7 - 30天）的增加，下丘脑的GABA能活性增强。另一方面，在纹状体中，连续7天重复高温暴露引起的GABA能活性增加在连续15 - 30天延长高温暴露后减弱。连续7天重复高温暴露也增强了大脑皮质的GABA能活性，在连续15天或30天重复高温暴露后该活性恢复正常。这些结果表明，长期（重复）高温暴露增强了下丘脑的GABA能活性，以通过调节体温来适应环境。
