Chakrabarti S, Ganguly A, Poddar M K
Department of Biochemistry, University of Calcutta, India.
Methods Find Exp Clin Pharmacol. 1991 Apr;13(3):165-73.
Single-dose diazepam (5 mg/kg i.p.) which increases central GABAergic activity alone normalizes the 6 multiple electroacupuncture (EA) (10 Hz, 1 volt, 10 min/day)-induced inhibition of GABAergic activity in Th and PM and thus reduces the EAA of adult male albino rats (120 +/- 10 g). On the contrary, single diazepam (5 mg/kg, i.p.) treatment to 15 multiple EA-(10 Hz, 1 volt, 10 min/day) exposed rats normalizes the 15 multiple EA-induced increase in thalamic GABAergic activity and fails to alter inhibition of GABAergic activity in CC and SC of 15 multiple EA-exposed rats. These results, thus, may be well correlated with the disinhibition of the 15 multiple EA-induced inhibition of analgesic response (assessed in terms of tail flick latency) with single diazepam treatment.
单剂量地西泮（腹腔注射5毫克/千克）可单独增强中枢γ-氨基丁酸（GABA）能活性，使成年雄性白化大鼠（120±10克）在6次多次电针（EA）（10赫兹、1伏、每天10分钟）诱导下丘脑和中脑导水管周围灰质（PM）中GABA能活性受到的抑制恢复正常，从而降低其兴奋性氨基酸（EAA）。相反，对15次多次电针（10赫兹、1伏、每天10分钟）处理的大鼠进行单剂量地西泮（腹腔注射5毫克/千克）治疗，可使15次多次电针诱导的丘脑GABA能活性增加恢复正常，且不会改变15次多次电针处理大鼠中脑中央灰质（CC）和上丘（SC）中GABA能活性受到的抑制。因此，这些结果可能与单剂量地西泮治疗解除15次多次电针诱导的镇痛反应抑制（以甩尾潜伏期评估）密切相关。
