Diazepam: effect on multiple electroacupuncture-induced changes in regional GABA of mammalian central nervous system.

Single-dose diazepam (5 mg/kg i.p.) which increases central GABAergic activity alone normalizes the 6 multiple electroacupuncture (EA) (10 Hz, 1 volt, 10 min/day)-induced inhibition of GABAergic activity in Th and PM and thus reduces the EAA of adult male albino rats (120 +/- 10 g). On the contrary, single diazepam (5 mg/kg, i.p.) treatment to 15 multiple EA-(10 Hz, 1 volt, 10 min/day) exposed rats normalizes the 15 multiple EA-induced increase in thalamic GABAergic activity and fails to alter inhibition of GABAergic activity in CC and SC of 15 multiple EA-exposed rats. These results, thus, may be well correlated with the disinhibition of the 15 multiple EA-induced inhibition of analgesic response (assessed in terms of tail flick latency) with single diazepam treatment.