Campbell I G, Carstens E, Watkins L R
Dept. of Animal Physiology, University of California, Davis, Davis, CA 95616 U.S.A. Dept. of Psychology, University of Colorado at Boulder, Boulder, CO 80309 U.S.A.
Pain. 1991 Jun;45(3):259-268. doi: 10.1016/0304-3959(91)90050-8.
The purpose of this study was to determine the reliability of flexion withdrawal magnitude as an indicator of pain sensation. In 10 healthy human volunteers, we compared the magnitude and latency of integrated biceps EMG with the subjects' rating of pain, using a visual analog scale, elicited by noxious radiant heat stimuli applied to the dorsal forearm. The magnitude and inverse latency of withdrawal, although variable, increased exponentially as a functions of stimulus temperature. The stimulus response functions for mean withdrawal magnitude and mean pain intensity were similar for lower stimulus temperatures, but at higher temperatures the withdrawal continued to increase exponentially whereas pain intensity reached a plateau. The pain intensity and withdrawal magnitude for each stimulus were poorly correlated. Under the conditions of this experiment, mean pain intensity and mean withdrawal magnitude were both well correlated with stimulus temperature, but the magnitude of withdrawal did not reliably reflect the intensity of pain sensation.
本研究的目的是确定屈肌退缩幅度作为痛觉指标的可靠性。在10名健康人类志愿者中，我们使用视觉模拟量表，比较了肱二头肌肌电图积分的幅度和潜伏期与受试者对疼痛的评分，疼痛由施加于前臂背侧的有害辐射热刺激引起。退缩的幅度和反向潜伏期虽然存在变化，但随着刺激温度的函数呈指数增加。对于较低的刺激温度，平均退缩幅度和平均疼痛强度的刺激反应函数相似，但在较高温度下，退缩继续呈指数增加，而疼痛强度达到平台期。每种刺激的疼痛强度和退缩幅度相关性较差。在本实验条件下，平均疼痛强度和平均退缩幅度均与刺激温度密切相关，但退缩幅度并不能可靠地反映痛觉强度。
