Wittstein Ilan S
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 568 Carnegie, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Curr Heart Fail Rep. 2008 Jun;5(2):61-8. doi: 10.1007/s11897-008-0011-3.
A unique syndrome of heart failure and transient left ventricular systolic dysfunction precipitated by acute emotional or physical stress has recently emerged in the medical literature. The syndrome is referred to by several names, including stress cardiomyopathy, takotsubo cardiomyopathy, left ventricular apical ballooning syndrome, and broken heart syndrome. Because most patients with stress cardiomyopathy present with chest pain, electrocardiographic abnormalities, elevated cardiac enzymes, and focal left ventricular wall motion abnormalities, it is not surprising that for years this syndrome went relatively unrecognized because physicians mistook it for acute myocardial infarction. As reports of this condition have increased worldwide during the past 5 years, it has become clear that stress cardiomyopathy has unique clinical features that can be readily distinguished from those of an acute myocardial infarction. This article reviews the clinical features of stress cardiomyopathy and discusses potential pathophysiologic mechanisms of this disorder.
一种由急性情绪或身体应激引发的独特的心力衰竭和短暂性左心室收缩功能障碍综合征最近在医学文献中出现。该综合征有多个名称，包括应激性心肌病、章鱼壶心肌病、左心室心尖气球样变综合征和心碎综合征。由于大多数应激性心肌病患者表现为胸痛、心电图异常、心肌酶升高以及局灶性左心室壁运动异常，多年来该综合征相对未被认识也就不足为奇了，因为医生将其误诊为急性心肌梗死。在过去5年里，随着全球范围内关于这种疾病的报告增多，很明显应激性心肌病具有可轻易与急性心肌梗死相区分的独特临床特征。本文回顾了应激性心肌病的临床特征，并讨论了这种疾病潜在的病理生理机制。
