种间重组在化脓性链球菌临床分离株的喹诺酮耐药决定区频繁发生。
Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes.
作者信息
Duesberg Christoph B, Malhotra-Kumar Surbhi, Goossens Herman, McGee Lesley, Klugman Keith P, Welte Tobias, Pletz Mathias W R
机构信息
Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
出版信息
Antimicrob Agents Chemother. 2008 Nov;52(11):4191-3. doi: 10.1128/AAC.00518-08. Epub 2008 Sep 2.
Abstract
Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.
摘要
仅偶有关于化脓性链球菌对氟喹诺酮耐药的报道，但最近一项比利时的监测研究发现其不敏感率为5.4%。通过对这些分离株的分析，我们发现parC喹诺酮耐药决定区域内的种间水平基因转移是一种常见现象，这可能导致了对氟喹诺酮的耐药性。
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