Chim Harvey, Schantz Jan-Thorsten, Gosain Arun K
Cleveland, Ohio; Singapore; and Lindau, Germany From the Department of Plastic Surgery, Case Western Reserve University, the Division of Plastic and Reconstructive Surgery, National University Hospital, and Bodenseeklinikum.
Plast Reconstr Surg. 2008 Sep;122(3):755-764. doi: 10.1097/PRS.0b013e31818236b7.
Recent developments in stem cell biology have led to the discovery of new sources of adult stem cells with potential for osteogenic differentiation.
In this article, the authors review the active field of research into new cell sources that are being investigated for use in bone tissue engineering. These include adipogenic, muscle, intraoral, dermal, and peripheral blood stem cells. The concept of "cell guidance," where cells are induced to home into a scaffold without the need for prior cell seeding, is also discussed.
These new cell sources have the advantages of decreased morbidity during harvesting from patients and increased availability compared with traditional sources of cells for bone tissue engineering, such as end organ-derived osteoblasts, bone marrow mesenchymal stem cells, and periosteal progenitor cells.
The move beyond common sources of cells is perhaps the single most important recent development in bone tissue engineering research.
干细胞生物学的最新进展已促成了具有成骨分化潜力的成体干细胞新来源的发现。
在本文中，作者回顾了正在研究用于骨组织工程的新细胞来源这一活跃的研究领域。这些来源包括脂肪生成细胞、肌肉细胞、口腔内细胞、真皮细胞和外周血干细胞。还讨论了“细胞引导”的概念，即诱导细胞归巢到支架中而无需预先接种细胞。
与用于骨组织工程的传统细胞来源（如终末器官来源的成骨细胞、骨髓间充质干细胞和骨膜祖细胞）相比，这些新细胞来源具有从患者身上获取时发病率降低以及可用性增加的优点。
超越常见细胞来源的转变可能是骨组织工程研究中近期最重要的单项进展。
