Kelloff G J, Peters R L, Donahoe R M, Stephenson J R, Aaronson S A
J Natl Cancer Inst. 1976 Jul;57(1):85-9. doi: 10.1093/jnci/57.1.85.
Natural tumor incidence and type C virus expression in HIH Swiss and BALB/c mice were investigated. The BALB/c mice showed a moderate incidence of lymphoreticular tumors containing infectious ecotropic virus. A second class of lymphoreticular tumors occurred with approximately the same incidence in both strains; though infectious virus could not be isolated from it, it contained the antigens of a common xenotropic virus. These xenotropic viral antigens were found in all NIH Swiss and BALB/c tumors examined and in normal hematopoietic tissues as well. The relationship between different classes of endogenous viruses and tumor development was discussed.
对HIH瑞士小鼠和BALB/c小鼠的自然肿瘤发生率及C型病毒表达进行了研究。BALB/c小鼠表现出含有传染性嗜亲性病毒的淋巴网状肿瘤的中等发生率。第二类淋巴网状肿瘤在两种品系中的发生率大致相同；虽然从中无法分离出传染性病毒，但它含有一种常见的异嗜性病毒的抗原。在所有检测的NIH瑞士小鼠和BALB/c小鼠肿瘤以及正常造血组织中都发现了这些异嗜性病毒抗原。讨论了不同类别的内源性病毒与肿瘤发生之间的关系。
