Kurohiji T, Yamashita Y, Kimitsuki H, Hiraki M, Isomoto H, Kakegawa T
First Dept. of Surgery, Kurume University, School of Medicine.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1908-11.
Ethanol injection therapy for rabbit VX2 cancer of the liver was performed to measure the extent of ethanol infiltration using normal hepatic tissue as control, to observe the serial histological findings after ethanol injection, and to determine the influence of the ethanol on survival days with VX2 cancer of the liver. The necrotic area caused by ethanol showed a significant dose-dependent correlation in the range of 0.1-1.0ml in the normal liver, and a significant correlation in the range of 0.2-1.0ml also in VX2 cancer of the liver. Further, VX2 cancer of the liver showed a significant extension in the number of survival days in the injection group after ethanol injection; 39.5 +/- 5.7 days in the injection group, against 29.3 +/- 2.9 days in the control group. In the successive observation of histological findings after injection, fibrosis started from the 3rd-5th day after ethanol injection and showed acceleration after the 7th day. Eosinophilic infiltration was seen in the VX2 cancer group but not among the controls. Since ethanol causes direct necrosis of the injected region, it is suggested that ethanol injection therapy is a potentially effective method of treating cancer of the liver.
对兔VX2肝癌进行乙醇注射治疗，以正常肝组织作为对照来测量乙醇浸润范围，观察乙醇注射后的系列组织学变化，并确定乙醇对VX2肝癌存活天数的影响。在正常肝脏中，乙醇所致坏死面积在0.1 - 1.0ml范围内呈显著的剂量依赖性相关，在VX2肝癌中，在0.2 - 1.0ml范围内也呈显著相关。此外，乙醇注射后，VX2肝癌注射组的存活天数显著延长；注射组为39.5±5.7天，而对照组为29.3±2.9天。在注射后组织学变化的连续观察中，纤维化从乙醇注射后第3 - 5天开始，第7天后加速。VX2癌组可见嗜酸性浸润，而对照组未见。由于乙醇可导致注射区域直接坏死，提示乙醇注射治疗可能是一种有效的肝癌治疗方法。
