Hromadka Michael, Collins James B, Reed Courtney, Han Li, Kolappa Kamal K, Cairns Bruce A, Andrady Tony, van Aalst John A
University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
J Burn Care Res. 2008 Sep-Oct;29(5):695-703. doi: 10.1097/BCR.0b013e31818480c9.
Nanotechnology is a growing field of manufactured materials with sizes less than 1 mum, and it is particularly useful in the field of medicine because these applications replicate components of a cell's in vivo environment. Nanofibers, which mimic collagen fibrils in the extracellular matrix (ECM), can be created from a host of natural and synthetic compounds and have multiple properties that may be beneficial to burn wound care. These properties include a large surface-area-to-volume ratio, high porosity, improved cell adherence, proliferation and migration, and controlled in vivo degradation rates. The large surface area of nanofiber mats allows for increased interaction with compounds and provides a mechanism for sustained release of antibiotics, analgesics, or growth factors into burn wounds; high porosity allows diffusion of nutrients and waste. Improved cell function on these scaffolds will promote healing. Controlled degradation rates of these scaffolds will promote scaffold absorption after its function is no longer required. The objective of this article is to review the current literature describing nanofibers and their potential application to burn care.
纳米技术是一个不断发展的领域，涉及尺寸小于1微米的人造材料，它在医学领域特别有用，因为这些应用能够复制细胞体内环境的组成部分。纳米纤维模仿细胞外基质（ECM）中的胶原纤维，可以由多种天然和合成化合物制成，并且具有多种可能有利于烧伤创面护理的特性。这些特性包括大的表面积与体积比、高孔隙率、改善细胞黏附、增殖和迁移以及可控的体内降解速率。纳米纤维垫的大表面积允许与化合物增加相互作用，并提供一种将抗生素、镇痛药或生长因子持续释放到烧伤创面的机制；高孔隙率允许营养物质和废物扩散。在这些支架上改善细胞功能将促进愈合。这些支架可控的降解速率将在其功能不再需要后促进支架吸收。本文的目的是综述描述纳米纤维及其在烧伤护理中潜在应用的当前文献。
