有症状儿童的幽门螺杆菌感染率下降：来自西弗吉尼亚州一家胃肠病诊所的13年（1993 - 2005年）回顾性分析
Helicobacter pylori infection rate decreases in symptomatic children: a retrospective analysis of 13 years (1993-2005) from a gastroenterology clinic in West Virginia.
作者信息
Elitsur Yoram, Dementieva Yulia, Rewalt Mary, Lawrence Zandra
机构信息
Department of Pediatrics, Gastroenterology Division, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
出版信息
J Clin Gastroenterol. 2009 Feb;43(2):147-51. doi: 10.1097/MCG.0b013e318157e4e7.
BACKGROUND
The rate of Helicobacter pylori is decreasing in the developed countries, but few long-term studies are available from the United States. We retrospectively assessed the annual H. pylori infection rate in symptomatic children seen in our clinic over a 13-year study period.
STUDY
A retrospective analysis of all children who had histologic diagnosis of H. pylori infection between January 1993 and December 2005 in our pediatric gastroenterology clinic was performed. The annual infection rate and the overall infection rate were calculated.
RESULTS
A total of 1743 upper endoscopy reports were reviewed, of which 212 (12.1%) were diagnosed with H. pylori infection. A significant decrease in mean annual H. pylori infection rate was noted in the last 6 years of the study period (2000 to 2005), compared with the first 7 years (1993 to 1999) (18.2% vs. 7.3%, respectively; P=0.001).
CONCLUSIONS
The incidence of H. pylori infection in symptomatic children in our clinic is decreasing. A national multicenter study will be needed to assess whether this drop is a local phenomenon or a national trend.
背景
在发达国家，幽门螺杆菌感染率正在下降，但美国的长期研究较少。我们回顾性评估了在13年研究期间在我们诊所就诊的有症状儿童的年度幽门螺杆菌感染率。
研究
对1993年1月至2005年12月期间在我们儿科胃肠病诊所经组织学诊断为幽门螺杆菌感染的所有儿童进行了回顾性分析。计算了年度感染率和总体感染率。
结果
共审查了1743份上消化道内镜检查报告，其中212份（12.1%）被诊断为幽门螺杆菌感染。与前7年（1993年至1999年）相比，研究期的最后6年（2000年至2005年）平均年度幽门螺杆菌感染率显著下降（分别为18.2%和7.3%；P=0.001）。
结论
我们诊所中有症状儿童的幽门螺杆菌感染率正在下降。需要进行一项全国性多中心研究，以评估这种下降是局部现象还是全国性趋势。
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