Wnt1过表达促进非小细胞肺癌的肿瘤进展。

Wnt1 overexpression promotes tumour progression in non-small cell lung cancer.

作者信息

Huang Cheng-Long, Liu Dage, Ishikawa Shinya, Nakashima Takashi, Nakashima Nariyasu, Yokomise Hiroyasu, Kadota Kyuichi, Ueno Masaki

机构信息

Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kita-Gun, Kagawa, Japan.

出版信息

Eur J Cancer. 2008 Nov;44(17):2680-8. doi: 10.1016/j.ejca.2008.08.004. Epub 2008 Sep 13.

DOI:10.1016/j.ejca.2008.08.004

PMID:18790633

Abstract

BACKGROUND

The Wnt gene family is involved in embryogenesis and tumourigenesis. We investigated the clinical significance of Wnt1 expression in non-small cell lung cancer (NSCLC).

METHOD

We studied 216 NSCLC patients. Immunohistochemistry was performed to investigate the Wnt1 expression in relation to the expression of beta-catenin and Wnt-targets, including c-Myc, Cyclin D1, VEGF-A and MMP-7. The Ki-67 proliferation index and the intratumoural microvessel density (IMD) were also evaluated.

RESULTS

The ratio of tumours with an aberrant beta-catenin expression was significantly higher in Wnt1-positive tumours than in Wnt1-negative tumours (p<0.0001). The Wnt1 expression significantly correlated with the expression of c-Myc (p<0.0001), Cyclin D1 (p<0.0001), VEGF-A (p=0.0160), MMP-7 (p<0.0001), the Ki-67 index (p=0.0048) and the IMD (p=0.0267). Furthermore, the Wnt1 status was a significant prognostic factor for NSCLC patients (p=0.0127).

CONCLUSIONS

The Wnt1 overexpression is associated with the expression of tumour-associated Wnt-targets, tumour proliferation, angiogenesis and a poor prognosis in NSCLCs.

摘要

背景

Wnt基因家族参与胚胎发育和肿瘤发生。我们研究了Wnt1表达在非小细胞肺癌（NSCLC）中的临床意义。

方法

我们研究了216例NSCLC患者。采用免疫组织化学方法研究Wnt1表达与β-连环蛋白及Wnt靶标（包括c-Myc、细胞周期蛋白D1、血管内皮生长因子A（VEGF-A）和基质金属蛋白酶-7（MMP-7））表达的关系。还评估了Ki-67增殖指数和肿瘤内微血管密度（IMD）。

结果

Wnt1阳性肿瘤中β-连环蛋白表达异常的肿瘤比例显著高于Wnt1阴性肿瘤（p<0.0001）。Wnt1表达与c-Myc（p<0.0001）、细胞周期蛋白D1（p<0.0001）、VEGF-A（p=0.0160）、MMP-7（p<0.0001）、Ki-67指数（p=0.0048）和IMD（p=0.0267）显著相关。此外，Wnt1状态是NSCLC患者的一个重要预后因素（p=0.0127）。